Previous studies reported that serum levels of insulin-like growth factor-1 (IGF-1) are elevated among patients with major depression; however, the longitudinal relationship between serum IGF-1 concentration and the onset of depression remains unclear. In this study, the relationship between serum IGF-1 concentration in the first trimester of pregnancy and the onset of postpartum depression was investigated using data from the Japan Environment and Children's Study (JECS). Among pregnant women enrolled in the JECS, 8791 women with available data of serum IGF-1 levels and psychological distress in the first trimester of pregnancy were analyzed in this study. In the first trimester, there was no association between serum IGF-1 levels and psychological distress among pregnant women. However, mothers with high serum IGF-1 levels in the first trimester of pregnancy had significantly lower risks of the onset of postpartum depression. Serum IGF-1 level in the first trimester of pregnancy may serve as a predictor of the development of postpartum depression.
Authors' abstract
Association between Serum Insulin-like Growth Factor-1 Concentration in the First Trimester of Pregnancy and Postpartum Depression
1 Hyogo Regional Center for the Japan Environment and Children's Study, Hyogo Medical University
2 Medical Center for Student Health, Kobe University (present affiliation)
3 Department of Public Health, School of Medicine, Hyogo Medical University
2 Medical Center for Student Health, Kobe University (present affiliation)
3 Department of Public Health, School of Medicine, Hyogo Medical University
Psychiatria et Neurologia Japonica
124: 593-600, 2022
＜Keywords：birth cohort, insulin-like growth factor-1, Japan Environment and Children's Study, postpartum depression, pregnant women＞
