A recent series of genetic analyses have demonstrated many common susceptibility genes between schizophrenic disorder and bipolar disorder. Furthermore, in pharmacotherapy, the same antipsychotic agents, particularly atypical neuroleptics are effective not only for schizophrenic disorder but also for affective disorder including depressive disorder. These findings support the notion of "primary affective disorders", which was proposed by W. Griesinger in the textbook "Mental pathology and therapeutics" (1845, 1861) referring to acute psychosis, including acute schizophrenia and early psychosis from a transdisorder viewpoint with therapeutic implications. Considering the dynamic framework proposed by W. Janzarik, the classification system of W. Griesinger should be reevaluated. The concept of schizophrenic disorder in the DSM-5 is as outdated as "dementia praecox", taking into account that the DSM-5 tries to capture the essential features of schizophrenic disorder in a coherent manner only as the cognitive disorder lacking therapeutic perspective. On the other hand, Kraepelin was correct to have proposed the concept of "dementia praecox" as this disorder is based fundamentally on the pathology of personality structure according to W. Janzarik. In deconstructing the transdisorder viewpoint of Griesinger and the dichotomic viewpoint of Kraepelin, the author proposed the core pathology of schizophrenic disorder to be characterized by primary language disorder, whereas that of manic-depressive disorder is characterized by primary affective disorder. Therefore, if we think logically, schizophrenic disorder may be an upper level manic-depressive disorder.
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