Characteristic changes to schizophrenia in DSM-5 are the downgrading of Schneiderian first-rank symptoms and the elimination of subtypes in schizophrenia. Since dimensional evaluation was officially suspended, schizophrenia with a flat face has been described in DSM-5. Recent genomic research, especially involving CNV analysis, has revealed that the categories in DSM are not based on biological information. Because "schizophrenia" was initially just a temporary diagnosis before the clarification of its biological basis, it will be divided when a clear etiology or causal genetic information is found in the future. Meanwhile, we have to follow its changes in a clinical setting due to the lack of alternatives to DSM. Since the practical "perspective" on the disorder is different from research to clarify its etiology, it is impossible to set one diagnostic criterion to satisfy the requirements from these two perspectives. It will be necessary to use the RDoC in future research for effective categorization.
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