Pharmacological treatments of psychiatric illness have been developed and many psychotropic drugs are now on the market. The body of safety information regarding psychotropic agents is so large that it is difficult for clinicians to consider all the details of possible adverse drug reactions (ADRs) in daily clinical practice. Although it is impossible to predict and prevent all occurrences of ADRs, many of them may be preventable. In this context, there is a strong need for compact manuals of diagnosis and treatment for ADRs arising from psychotropic agents that are likely to be used in daily practice. Under the auspices of the Japanese Society of Psychiatry and Neurology, a task force was convened to answer this need. This review focuses on the general considerations of ADRs with psychotropic agents, based on discussions of the task force. We also discuss the guidelines for drug safety monitoring, targeted towards specific psychiatric disorders or patients taking specific classes of drugs. Finally, we introduce the Adverse Drug Reactions Relief System in Japan.
<Authors' abstract>
Adverse Drug Reactions of Psychotropic Agents: Adverse Drug Reactions and Safety
Monitoring of Psychotropic Agents
1 Department of Neuropsychiatry, Kyushu University Hospital
2 Task Force to Develop a Diagnosis and Treatment Manual for Psychotropic Medication Side Effects
3 Department of Psychiatry, NHO Kyushu Medical Center
4 Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University
5 Department of Neuropsychiatry, Keio University School of Medicine
6 Fuji Toranomon Health Promotion Center
7 Department of Psychiatry, International University of Health and Welfare Atami Hospital
8 Department of Psychiatry, Niigata University Graduated School of Medical and Dental Sciences
9 Department of Psychiatry and Neuroscience, Gunma University Graduate School of Medicine
10 Keio Center for Clinical Research
11 Department of Psychiatry, International University of Health and Welfare Hospital
12 Department of Psychiatry, Tokyo Women's Medical University, Medical Center East
2 Task Force to Develop a Diagnosis and Treatment Manual for Psychotropic Medication Side Effects
3 Department of Psychiatry, NHO Kyushu Medical Center
4 Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University
5 Department of Neuropsychiatry, Keio University School of Medicine
6 Fuji Toranomon Health Promotion Center
7 Department of Psychiatry, International University of Health and Welfare Atami Hospital
8 Department of Psychiatry, Niigata University Graduated School of Medical and Dental Sciences
9 Department of Psychiatry and Neuroscience, Gunma University Graduate School of Medicine
10 Keio Center for Clinical Research
11 Department of Psychiatry, International University of Health and Welfare Hospital
12 Department of Psychiatry, Tokyo Women's Medical University, Medical Center East
Psychiatria et Neurologia Japonica
116: 735-745, 2014
Accepted in revised form: 18 April 2014.
Accepted in revised form: 18 April 2014.
<Keywords:psychotropic drugs, adverse drug reactions, drug safety monitoring, Adverse Drug Reactions Relief System>