In the past two decades, we have identified various mutant genes associated with idiopathic epilepsies. Many of these mutant genes encode several ion channel subunits or functionally related proteins, leading to the classification of epilepsy as channelopathy. Currently,after the onset of epilepsy,we prescribe the anticonvulsant medication ; however, anticonvulsants inhibit epileptic seizure and probably prevent progression of secondary epileptogenesis which is induced by epileptic seizure. Despite these efforts, we have no effective medication to prevent primary epileptogenesis.Thus,to develop novel strategies for the treatment of epilepsy, including preventing onset and complete recovery, we should develop true antiepileptic drug via generation of the genetic animal models of epilepsy according to the validation criteria.