Drug overdose is a serious public health issue and fatal cases have been reported from various fields of medicine. This case-control analysis assessed the comparison between fatal overdose cases in the special wards of Tokyo Metropolitan area and prescribed psychotropic drugs in Tokyo in 2009-2010. It was suggested that the prescribed drugs serve as a direct cause of death in overdose cases. Furthermore, pentobarbital calcium, chlorpromazine-promethazine-phenobarbital, levomepromazine and flunitrazepam were identified as drugs with a high risk of fatal overdose. It is encouraged to prudently verify the intended application and usage of such psychotropic drugs in each case upon their prescription. This is the first study in Japan to identify psychotropic drugs with a high risk of fatal overdose by case-control study.
<Authors' abstract>
Identification of Psychotropic Drugs Attributed to Fatal Overdose -A Case-control Study by Data from the Tokyo Medical Examiner's Office and Prescriptions
1 Tokyo Medical Examiner's Office
2 Institute for Health Economics and Policy, Association for Health Economics Research and Social Insurance and Welfare
3 National Center of Neurology and Psychology
4 Tokyo Medical Examiner's Office
2 Institute for Health Economics and Policy, Association for Health Economics Research and Social Insurance and Welfare
3 National Center of Neurology and Psychology
4 Tokyo Medical Examiner's Office
Psychiatria et Neurologia Japonica
118: 3-13, 2016
Accepted in revised form: 2 October 2015.
Accepted in revised form: 2 October 2015.
＜Keywords：drug poisoning, barbiturates, hypnotic, suicide, overdose＞
