Treatment of major depressive disorder (MDD) can include a variety of biopsychosocial approaches. In medical practice, antidepressant drugs are the most common treatment for moderate to severe depressive episodes; however, their efficacy is limited. Many depressed patients are considered treatment-resistant, with 33% ssion after ≥3 treatment trials. A systemic review and meta-analysis revealed that repetitive transcranial magnetic stimulation (rTMS) may be reasonably considered for patients with MDD and ≥2 prior failures of antidepressant treatment. No rTMS devices have been approved by the Japanese Pharmaceuticals and Medical Devices Agency, which has resulted in its off-label use; therefore, to offer better care for cases of treatment-resistant MDD, we should continue efforts to seek the introduction of rTMS to Japan.
<Author's abstract>
Toward the Introduction of Repetitive Transcranial Magnetic Stimulation in Japan to Treat Antidepressant-resistant Depression
Department of Psychiatry, International University of Health and Welfare Hospital
Gunma University Graduate School of Medicine
Gunma University Graduate School of Medicine
Psychiatria et Neurologia Japonica
117: 120-125, 2015
<Keywords:repetitive transcranial magnetic stimulation (rTMS), treatment-resistant, major depressive disorder, modified electroconvulsive therapy (mECT), brain imaging analysis>