In treating bipolar disorder,specific psychotherapies in adjunct to pharmacotherapy have been shown to be effective in preventing new episodes and treating depressive episodes. Among those,interpersonal and social rhythm therapy（IPSRT）developed by Frank,amalgamation of interpersonal psychotherapy（IPT）with behavioral therapy focused on social rhythm has been shown to be an efficacious adjunct to mediation in preventing new episodes in bipolar I patients and in treating depression in bipolar I and II disorder. IPSRT has also been shown to enhance total functioning,relationship functioning and life satisfaction among patients with bipolar disorder,even after pretreatment functioning and concurrent depression were covaried.
 IPSRT was designed to directly address the major pathways to recurrence in bipolar disorder, namely medication nonadherence, stressful life events, and disruptions in social rhythms. IPT, originated by Klerman et al., is a strategic time-limited psychotherapy focused on one or two of four current interpersonal problem areas（ie, grief, interpersonal role disputes, role transitions, and interpersonal dificits）. In IPSRT, the fifth problem area “grief for the lost healthy self”has been added in order to promote acceptance of the diagnosis and the need for life-long treatment.
 Social rhythm therapy is a behavioral approach aiming at increasing regularity of social rhythms using the Social Rhythm Metric（SRM）, a chart to record daily social activities including how stimulating they were, developed from observation that disruptions in social rhythms often trigger affective episodes in patients with bipolar disorder. IPSRT also appears to be a promising intervention for a subset of individuals with bipolar II depression as monotherapy for the acute treatment.