The therapeutic guideline for the treatment of a manic episode is as follows : Firstly, lithium is the prime recommendation. In the case of a severe manic episode,the combination of lithium and atypical antipsychotic drug is recommended. Secondly, valproate, atypical antipsychotic drugs, and carbamazepine are recommended. In the case of a severe manic episode, the combination of valproate and an atypical antipsychotic drug is recommended. Finally, the combination of mood stabilizers, or the combination of mood stabilizer and typical antipsychotic drug, and electroconvulsive therapy are recommended in refractory situations.