In this paper,we firstly reviewed the hypotheses of etiologies concerning high prevalence of comorbidity of eating disorder（ED）and substance use disorder（SUD）. Secondary, our previous studies on comorbidity of ED and SUD were presented,which suggested that female patients with both of ED and SUD were likely to have clinical features of “multi-impulsive bulimia,”while they might select the substance abuse for body-weight control. Finally,we discussed clinical implications of comorbidity of ED and SUD in the view of suicide prevention.