Working in close cooperation with the clinician in charge, the human resource department, and line managers, the occupational physician plays a key role in employees’healthy adaptation to the workplace. In the workplace, it is not sufficient for an employee’s depressive symptoms to disappear ; it is also necessary that the employee be able to function according to job demands. It is becoming increasing difficult to distinguish between depression and related disorders that manifest depressive symptoms, such as adjustment disorder and personality issues. Using a complex case of dysthymia in the workplace, the author examines the management of such cases, as well as ways of collaborating closely with the clinician in charge.